International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Sedation is essential for facilitating the smooth execution of radiological procedures, especially in pediatric patients who may experience distress and apprehension during imaging. Among the available sedative agents, midazolam has been widely recognized for its effectiveness and favorable safety profile in pediatric practice. This research aimed to evaluate and compare the efficacy and safety of intravenous (IV) midazolam versus intranasal (IN) midazolam for sedation in pediatric patients undergoing radiological imaging. This prospective, randomized clinical study included children between 6 months and 8 years of age who required sedation for computed tomography (CT) imaging. A total of 112 participants were enrolled, with 56 children randomly assigned to each sedation method (IV midazolam or IN midazolam) using randomization. Sedation was administered according to the assigned group and imaging procedures were performed under sedation. The primary parameters assessed included sedation effectiveness and safety, focusing on sedation onset, depth of sedation, procedure completion rate, adverse effects and recovery duration. The time required to achieve sedation was shorter in the intravenous midazolam group compared to the intranasal group. No significant differences were observed in sedation onset and duration based on age or sex. The overall success rate of completing the radiological procedure was comparable between the two groups. However, the intranasal midazolam group demonstrated a faster recovery. Motion artifacts at the end of the procedure were more frequent in the intranasal group. Adverse effects, including severe complications such as respiratory distress and oxygen desaturation, were more commonly reported in patients receiving intravenous midazolam. Given its ease of administration, fewer side effects despite higher doses, and rapid recovery time, intranasal midazolam may serve as a practical sedation option for short, non‐invasive imaging procedures such as CT scans.
How to cite this article:
Gaganpal Singh and Gajendra Kumar. Midazolam for Peadiatric Sedation: Assessing Efficacy of Intravenous vs Intransal Route.
DOI: https://doi.org/10.36478/10.36478/makijtm.2016.304.307
URL: https://www.makhillpublications.co/view-article/1816-3319/10.36478/makijtm.2016.304.307