Research Journal of Biological Sciences
ISSN: Online 1993-6087ISSN: Print 1815-8846
Abstract
In the present study, researchers designed a Pharmacophore Model chalconesemicarbazone which is having hydrogen acceptor site, hydrogen donor site, lipophilic site, etc., using Ligandscout-2.02 software. A series of chalcone semicarbazones was synthesized and evaluated for their anti-fungal activity by Paper Disk Diffusion Method. Based on the results of an anti-fungal study, compound CS-10 was the most active compound. It was observed that methoxy substitution in aldehydic moiety and hydroxyl substitution in the acetophenic moiety significantly increased anti-microbial spectrum against fungi.
How to cite this article:
Manmohan Singhal and Arindam Paul. Evaluation of Anti-Fungal Activity of Synthesized Chalcone Semicarbazone Derivatives.
DOI: https://doi.org/10.36478/rjbsci.2011.632.634
URL: https://www.makhillpublications.co/view-article/1815-8846/rjbsci.2011.632.634