Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Clonidine affects the blood pressure in a complex fashion after neuraxial or systemic administration because of opposing action at multiple sites. In the nucleus tractus solitarius and locus coeruleus of the brain stem, activation of post‐synaptic a2 adrenoreceptors reduces sympathetic drive. It also activates noradrenergic imidazoline preferring binding sites in the lateral reticular nucleus producing hypotension and anti‐arrythmogenic action. Patients fulfilling the required essential criteria were selected and 90 patients were randomly allocated to following 2 groups: Group BC (45 No.)‐Spinal Bupivacaine with Clonidine. Group BM (45 No.)‐Spinal Bupivacaine with Midazolam. Patient allocation was made based on computer generated numbers and sealed envelope method. The study solution for spinal anaesthesia was prepared separately by a person not involved in the patient care. Patients and Anaesthesiologists were blinded to both the study groups. The mean intra‐operative fall of heart rate in BC group was 14bpm (range‐10‐40bpm) with a mean maximum fall of 21.4±7.2bpm. On the other hand, these figures in BM group were 3 bpm (range‐2‐25 bpm) and 12.5±4.4 bpm only.
How to cite this article:
R. Thanuja, C. Shalini, M.G. Harshitha and B. Geethashree. Clonidine (30μg) and Midazolam (2mg) as Intrathecal Adjuvants to Bupivacaine: Hemodynamic Changes.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.271.274
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.271.274