Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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A Prospective Study of Relationship Between Clinical and Sociodemographic Factors and High Sensitivity C‐Reactive Protient (HS‐CRP) Levels in Patients of Depression With Suicidal Behavior
Manisha Menon, Virendra Singh Pal and Vijay Niranjan
Page: 340-344 | Received 11 Sep 2024, Published online: 27 Nov 2024
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Abstract
Depression is a major mental health disorder associated with significant morbidity and mortality, particularly through suicidal behavior. Emerging evidence suggests inflammation, marked by elevated high‐sensitivity C‐reactive protein (hs‐CRP), may play a role in the pathophysiology of depression and suicidality. A prospective, observational study was conducted at Mahatma Gandhi Memorial Medical College and MY Hospital, Indore, Madhya Pradesh, over 18 months. The study included 60 drug‐naïve or drug‐free patients diagnosed with depression (F32/F33 based on ICD‐10) exhibiting suicidal behavior. Sociodemographic and clinical data were collected and hs‐CRP levels were measured at baseline and after four weeks of treatment. Depression severity was assessed using the Hamilton Depression Rating Scale (HAM‐D) and suicidal behavior was evaluated using the Suicide Behaviors Questionnaire‐ Revised (SBQ‐R). The majority of participants (45%) were aged 18‐30 years, with 51.7% being male. Most were married (51.7%), belonged to the upper‐middle socioeconomic status (41.7%) and resided in urban areas (65%). Depression severity significantly improved over four weeks, with HAM‐D scores decreasing from 25.26±5.937 at baseline to 14.78±4.720 (*P*<0.001). hs‐CRP levels also showed a significant reduction, from 1.10±0.97mg/L at baseline to 0.91±0.038mg/L at four weeks (*P*<0.001). 88.3% of subjects exhibited high suicidal risk (SBQ‐R score $7). This study highlights the significant association between hs‐CRP levels, depression severity and suicidal behavior. The findings underscore the importance of considering inflammatory markers in the assessment and management of depression. Future research should investigate inflammation‐targeted interventions to reduce suicidality in depressed individuals.
How to cite this article:
Manisha Menon, Virendra Singh Pal and Vijay Niranjan. A Prospective Study of Relationship Between Clinical and Sociodemographic Factors and High Sensitivity C‐Reactive Protient (HS‐CRP) Levels in Patients of Depression With Suicidal Behavior.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.340.344
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.340.344