Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Comparison of Clinical Outcome and Dosimetric Parameters of Three‐Dimensional Conformal Radiotherapy Versus Intensity Modulated Radiotherapy in Patients with Head and Neck Squamous Cell Carcinoma: A Prospective Two Armed Observational Study
Sumana Samaddar, Krishnangshu Bhanja Choudhury and Shatarupa Dutta
Page: 460-466 | Received 20 Aug 2024, Published online: 03 Dec 2024
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Abstract
This study aimed to compare the clinical outcomes and dosimetric parameters of three‐dimensional conformal radiotherapy (3D‐CRT) and intensity‐modulated radiotherapy (IMRT) in treating patients with head and neck squamous cell carcinoma (HNSCC). According to NCCN Guideline, ‘Head and Neck cancer’ refers to cancer of the upper aerodigestive tract, arising from the lip, oral cavity, pharynx, larynx, paranasal sinuses., salivary gland cancers, mucosal melanoma and occult primary cancers. Squamous cell carcinoma is the histological type in >90% of all Head and Neck tumors. Worldwide, Squamous cell carcinoma of Head and Neck is the 7th most common cancer, having an annual incidence of 7, 00,000 (approximately) and mortality rate of 3, 50,000 in 2018. To study the response and dosimetric parameters after radical treatment in patients with Head and Neck Squamous Cell carcinoma undergoing radical concomitant chemoradiation with either Three‐Dimensional Conformal Radiotherapy (3‐DCRT) or Intensity modulated radiotherapy (IMRT). This is two tailed, open labeled, comparative, single institutional observational study. Place of study is R. G. Kar Medical College and Hospital, 1, Khudiram Bose Sarani. Kolkata‐ 700004. The study duration is from January 2021‐August 2022 and Sample Size is 100patients. The functional status was assessed as per ECOG (Eastern Cooperative Oncology Group) Performance status. The distribution of the patients in both the arms according to their Performance status were also comparable (p value=0.144). In studies comparing Three‐Dimensional Conformal Radiotherapy (3D‐CRT) and Intensity‐Modulated Radiotherapy (IMRT) for treating head and neck squamous cell carcinoma (HNSCC), IMRT generally demonstrates superior dosimetric advantages, offering improved target coverage and sparing of surrounding healthy tissues. IMRT's ability to more precisely conform the radiation dose to the tumor shape reduces the risk of damage to critical structures such as the salivary glands, spinal cord and oral cavity.
How to cite this article:
Sumana Samaddar, Krishnangshu Bhanja Choudhury and Shatarupa Dutta. Comparison of Clinical Outcome and Dosimetric Parameters of Three‐Dimensional Conformal Radiotherapy Versus Intensity Modulated Radiotherapy in Patients with Head and Neck Squamous Cell Carcinoma: A Prospective Two Armed Observational Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.460.466
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.460.466