Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Papanicolaou Society of Cytopathology System vs World Health Organization of Reporting System for Pancreaticobiliary Cytopathology‐Comparison of Risk of Malignancy and Diagnostic Predictive Values: A 3 Year Retrospective Study in India
Catherine Aishwarya, N. Divya, N. Kavya, R.K. Radha, S. Prathima and Jaydeep GearhalliLakshmipathy
Page: 512-517 | Received 25 Sep 2024, Published online: 05 Dec 2024
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Abstract
Pancreatic carcinoma is a rare entity with a poor survival rate due to late presentation and limited diagnostic modalities. This retrospective study aimed to evaluate the diagnostic performance of the Papanicolaou Society of Cytopathology (PSC) system and the World Health Organization (WHO) system for pancreaticobiliary cytology reporting. A total of 77 cases with pancreatic lesions were evaluated at the Department of Pathology, Vydehi Institute of Medical Sciences and Research Centre for a period of 3 years, i.e. January 2021 to December 2023, using both PSC and WHO systems. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were calculated for both systems. The Risk of Malignancy (ROM) was also estimated for each diagnostic category. Both systems showed high sensitivity, specificity and diagnostic accuracy. However, the WHO system had higher sensitivity (95.65% vs 93.47%), NPV (93.75% vs 90.90%) and diagnostic accuracy (96.10% vs 94.81%) compared to the PSC system. The ROM was also accurately estimated by both systems, with the WHO system showing a slightly better performance in stratifying the risk of malignancy. Both PSC and WHO systems are reliable for pancreaticobiliary cytology reporting. However, the WHO system may be a more effective tool for risk stratification and diagnosis of pancreaticobiliary lesions, with a slightly better performance in estimating the ROM. Future studies with larger sample sizes and longer follow‐up periods are needed to further validate these findings.
How to cite this article:
Catherine Aishwarya, N. Divya, N. Kavya, R.K. Radha, S. Prathima and Jaydeep GearhalliLakshmipathy. Papanicolaou Society of Cytopathology System vs World Health Organization of Reporting System for Pancreaticobiliary Cytopathology‐Comparison of Risk of Malignancy and Diagnostic Predictive Values: A 3 Year Retrospective Study in India.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.512.517
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.512.517