Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Acute pancreatitis is a common and serious condition with a mortality rate of 20‐40% and high morbidity due to systemic complications. Despite various causes, the final result is the premature activation and retention of proteolytic enzymes along with disturbance in pancreatic micro circulation aggravating the severity. Standard treatment includes fluid management, nutritional care, gastrointestinal decompression and antibiotics when needed. Low molecular weight heparin can reduce the release of cytokine and inflammatory mediators, improving pancreatic micro circulation and thereby reducing the severity of pancreatitis. The aim is to study the Effect of LMWH in treatment of acute pancreatitis. Our study involved 130 patients divided into two groups: GROUP A (Control Group) received conventional treatment for acute pancreatitis (n=65) and GROUP B (Observation Group) received conventional treatment plus LMWH [1mg/kg] (n=65). Results showed that out of 130 patients, 125 recovered and 5 died, all from the control group. There was no significant difference in APACHE II scores between the groups at admission. After 7 days of treatment, the APACHE II scores were significantly lower in the observation group (those treated with heparin) compared to the control group. Additionally, the mean hospital stay was significantly shorter in the observation group. LMWH can significantly enhance the effectiveness of conventional acute pancreatitis treatment, markedly reducing its mortality.
How to cite this article:
S.B. Rajashekhar, Desai Mahesh Srinath, Prashant and P.B. Shabbeer Pasha. Effect of Low Molecular Weight Heparin in Treatment of Acute Pancreatitis.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.536.539
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.536.539