Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Prospective Randomized Clinical Case Control Study of Injection Magnesium Sulphate in Organophosphorus Poisoning at Tertiary Care Centre in Tamilnadu
Jayaprasad Rajarajan, Senthil Kumaran Arjunan, Banugopanar Balaraman and Karthikeyan Naganathan
Page: 630-632 | Received 03 Nov 2024, Published online: 25 Dec 2024
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Abstract
Organophosphorus compounds have a wide range and complexity of effects on human physiology. MgSO4 inhibits the release of acetylcholine in peripheral sympathetic and parasympathetic synapses as well as in the central nervous system. By acting on the N‐methyl‐D‐aspartate receptor, it reduces the arrhythmia brought on by OPC poisoning and atropine, reverses neuromuscular weakness in the peripheral nervous system and inhibits OPCP overstimulation in the central nervous system. The is to study the effect of magnesium sulphate on outcome in organophosphorus poisoning admitted in Government thiruvannamalai Medical College and Hospital. A prospective randomized clinical control study at Department of general medicine, Government thiruvannamalai Medical College and Hospital, Thiruvannamalai in Patients admitted with organophosphorus poisoning. The study duration is 18 months. The total Sample size is 100 with People receiving magnesium sulphate: 50 (One group of people with administration of 4 grams of 20%magnesium sulphate) and Control group: 50 (One group of people without administration of magnesium sulphate). Comparison between the response after Magnesium sulphate of the case and control group were observed. The dose requirement of atropine, duration of ICU stay and requirement of intubation after 24 hrs were significantly decreased in case group than control. OPC poisoning may be effectively treated with intravenous Magnesium sulphate therapy in combination with atropine and P2AM. We find that administering Magnesium sulphate at an early stage in patients with OPC poisoning results with reduced morbidity.
How to cite this article:
Jayaprasad Rajarajan, Senthil Kumaran Arjunan, Banugopanar Balaraman and Karthikeyan Naganathan. Prospective Randomized Clinical Case Control Study of Injection Magnesium Sulphate in Organophosphorus Poisoning at Tertiary Care Centre in Tamilnadu.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.630.632
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.630.632