Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The levels of serum uric acid in ischemic stroke has been has been questioned for decades. Evidence from epidemiological studies suggest that the elevated SUA levels may predict an increased risk for cerebrovascular (CV) events including stroke. SUA can work as pro‐oxidant under certain circumstances, particularly if the levels of other antioxidants like ascorbic acid are low. Various studies have shown that uric acid can result in endothelial dysfunction which can lead to vascular disease. An association between SUA and inflammatory marker shaves also been discovered More over therapeutic modalities with a SUA lowering potential have been shown to reduce CV disease morbidity and mortality. The present study was conducted in Adichunchanagiri hospital and research institute, BG Nagara Mandya. 100 patients of first ever on life time acute ischemic stroke were included. the blood samples like complete hemogram, serum uric acid, blood sugar, lipid profile was taken within 24hours of onset of stroke and sent for biochemical analysis. The patients were further evaluated for presence of additional risk factors like hypertension, diabetes, coronary artery disease, adverse lipid profile, smoking and alcoholism. 100 patients participated in the study in which 82 males and 18 females. Majority Were in the age group of >50 yrs, constituted 48%of stroke population mean uricacid levels in males is 6.49% and in females its 5.83%. age wise distribution of uricacid is statistically significant, as age advances uricacid also rises. Diabetes constitutes major risk factor with 49% of the population with 51.2mg/dl and 38.9% females. Hypertension ranks second as risk factors, constitutes 46% of study populations 48.8% males and 33.3% females. CAD is associated in 38% of study populations with 40.2% males and female 27.8% females. 45% stroke population has adverse lipid profile, 53% affected with stroke are smokers and 51% are alcoholics. Our study shows that elevated serum uric acid is strongly associated with an increased risk for development of acute ischemic stroke, also the relation between other risk factors and raised uric acid levels association between elevated serum uric acid and ischemic stroke may need to be considered especially when treating elderly patients, Diabetes, CAD and Hypertension.
How to cite this article:
J. Madhusudan, B. Sandhya Rani and Ravi B. Nagarajai. Serum Uric Acid Levels in Predicting the Clinical Course and Outcome in Acute Ischemic Stroke Patients.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.678.683
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.678.683