Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Chronic kidney disease (CKD) is associated with significant hematological abnormalities, including anemia, leukopenia and thrombocytopenia, which contribute to increased morbidity and mortality. This study aims to assess the prevalence and severity of these hematological changes across different CKD stages. A cross‐sectional observational study was conducted among CKD patients at a tertiary care hospital. Hematological parameters, including hemoglobin (Hb), total leukocyte count (TLC) and platelet count, were analyzed across different CKD stages. The data were statistically evaluated to determine associations between CKD severity and hematological abnormalities. Anemia was observed in 97.33% of Stage 3 CKD patients, with all Stage 4 and Stage 5 patients being anemic. The severity of anemia increased with CKD progression, with 16% of Stage 5 patients exhibiting severe anemia (Hb <7 g/dL). Leukopenia was significantly associated with advanced CKD stages, with a decline in mean WBC count from 7.41×109/L in Stage 3‐5.09×109/L in Stage 5 CKD. Thrombocytopenia was more pronounced in late‐stage CKD, contributing to an increased risk of bleeding complications. Diabetes mellitus (37.78%) and hypertension (30.67%) were the leading etiologies of CKD. Hematological abnormalities worsen with CKD progression, emphasizing the need for early detection and management. Routine monitoring of hemoglobin, leukocyte count and platelet count is crucial for improving clinical outcomes in CKD patients.
How to cite this article:
G. Ambedkar, A. Ashok Kumar, R. Satish Kumar, C.D. Aranendran and M.S. Jegan. Across‐Sectional Study on Hematological Abnormalities in Chronic Kidney Disease.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.12.730.734
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.12.730.734