Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Prelabor Rupture of Membranes (PROM) at term poses significant clinical challenges, often necessitating timely induction of labor to reduce maternal and neonatal risks. This study compares the efficacy and safety of oral misoprostol versus intravenous oxytocin for labor induction in women with PROM. The primary aim was to compare the induction-todelivery interval and mode of delivery between oral misoprostol and oxytocin. Secondary objectives included evaluating maternal and neonatal outcomes associated with both methods. This randomized controlled trial was conducted at Sree Mookambika Institute of Medical Sciences, Tamil Nadu, from January to December 2024. A total of 152 term pregnant women with PROM were randomly assigned to receive either oral misoprostol (25 μg every 6 hours, up to 4 doses) or intravenous oxytocin (titrated infusion). The primary outcome was the induction-to-vaginal delivery interval. Secondary outcomes included mode of delivery, maternal complications and neonatal outcomes. The mean induction-to-delivery time was significantly longer in the misoprostol group (10.15±5.66 hrs) compared to the oxytocin group (7.75±2.90 hrs, p<0.001). Vaginal delivery rates were similar (misoprostol 82%, oxytocin 87%). Maternal complications, including pyrexia and uterine hyperstimulation and neonatal outcomes such as Apgar scores and NICU admissions showed no significant differences between groups. Both oral misoprostol and intravenous oxytocin are effective and safe for labor induction in PROM. Misoprostol is associated with a longer induction-to-delivery interval but comparable maternal and neonatal outcomes.
How to cite this article:
L. Bhuvaneswari and Pranadeep Reddy Inukollu. Oral Misoprostol vs Oxytocin: A Comparative Study in Induction of Labour in Prelabour Rupture of membrane.
DOI: https://doi.org/10.36478/makrjms.2024.11.677.680
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.11.677.680