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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A Study of Predicting Outcomes in Acute Organophosphate Poisoning Using Poisoning Severity Score, Glasgow Coma Scale and Corrected QT Interval

Eguturi Krishna Reddy, M.S. Mulimani, Ninad Mallanna Mulimani and Shravan Kumar Potkar
Page: 174-179 | Received 20 Aug 2024, Published online: 19 Nov 2024

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https://doi.org/makrjms.2024.12.174.179

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Abstract

Acute organophosphate poisoning is a significant worldwide health issue, especially in areas with limited access to healthcare resources. Rapid diagnosis of the severity of poisoning is essential for devising therapeutic options and determining patient outcomes. The study evaluated the prognostic significance of the Poisoning Severity Score, Glasgow Coma Scale and Corrected QT Interval in determining the severity and predicting the outcomes of acute OP poisoning. A retrospective analysis of 61 patients admitted to Shri B M Patil Medical College and Research Center, Vijayapura, over 18 months from August 2022 to January 2024, was conducted. The data collected included demographics, clinical features, ECG findings, treatment modalities and patient outcomes, focusing on organophosphate substance intake or exposure. The study involved 61 patients, 52.5% male and 47.5% female, with a majority aged 20‐39. The most common opioid (OP) component was unidentified, followed by Malathion and Acephate. Most patients had mild to moderate PSS scores, with Grade 1 representing 40.9% of responses and Grade 2 accounting for 27.9% and 17. Grade 3 represented 31.1% and Grade 4 18.0%, respectively. GCS scores indicated mild to moderate impairment (19.6%). Significant ECG findings included patients with prolonged QTc intervals, which showed a higher association with mechanical ventilation but was statistically insignificant in determining outcomes. A significant proportion of patients who did not survive had PSS Grade 3, suggesting higher PSS grades are strongly associated with lesser outcomes. The study highlights the importance of PSS, GCS and QTc interval in predicting outcomes in acute OP poisoning, emphasizing the need for early assessment and intervention to improve patient prognosis and reduce mortality and calls for further research in QTc.

How to cite this article:

Eguturi Krishna Reddy, M.S. Mulimani, Ninad Mallanna Mulimani and Shravan Kumar Potkar. A Study of Predicting Outcomes in Acute Organophosphate Poisoning Using Poisoning Severity Score, Glasgow Coma Scale and Corrected QT Interval.
DOI: https://doi.org/10.36478/makrjms.2024.12.174.179
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.174.179