Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
middle‐income countries. Early detection through screening methods such as Pap smear cytology and histopathology is crucial for reducing the incidence and mortality of cervical cancer. This study aims to compare the diagnostic accuracy of Pap smear cytology and histopathological examination in detecting cervical lesions in women from Tamil Nadu. A cross‐sectional study was conducted at a tertiary care hospital in Tamil Nadu, involving 150 women with clinical symptoms suggestive of cervical lesions. All participants underwent Pap smear cytology, followed by histopathological examination of cervical biopsies. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of Pap smear were calculated and compared to histopathology results. The majority of women (53.3%) had normal Pap smear findings, while 16.7% were diagnosed with low‐grade squamous intraepithelial lesions (LSIL) and 13.3% with high‐grade squamous intraepithelial lesions (HSIL). Histopathology confirmed chronic cervicitis in 46.7% of cases, followed by cervical intraepithelial neoplasia (CIN) and invasive carcinoma. The overall concordance between Pap smear and histopathology was 87.8%, with a sensitivity of 85.7%, specificity of 91.4%, and a PPV of 89.7%. Pap smear cytology demonstrated a high diagnostic accuracy in detecting cervical lesions, though histopathology remains the gold standard for definitive diagnosis. The combined use of both methods enhances early detection and appropriate management of cervical pathology in high‐risk populations. Regular screening with Pap smear, followed by histopathological confirmation for abnormal results, is recommended to reduce cervical cancer burden.
How to cite this article:
Lilarani Vijayaraghavan, Anisha Nazar and G. Rajan. Comparative Study of Pap Smear Cytology and Histopathology in Lesions of Cervix.
DOI: https://doi.org/10.36478/makrjms.2024.12.834.838
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.834.838