Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Organophosphates (OPs) are a diverse group of chemical compounds formed by esterifying phosphoric acid with alcohol. Common uses for these compounds include insecticides, herbicides, and nerve agents in chemical warfare. This study aims to determine the prognostic value of serum CPK levels in OP poisoning and compare its predictive accuracy with the POP Scale. By integrating biochemical markers with clinical evaluation, the study seeks to improve early risk stratification, ensuring that high‐risk patients receive timely and appropriate medical attention. This was a prospective observational study conducted in the Department of General Medicine at PESIMSR Hospital over a period of 18 months. The study population consisted of patients admitted with organophosphate poisoning during the study period. Patients were selected using a purposive sampling technique. Based on the study conducted by Bhattacharyya K. et al., the required sample size was estimated to be 100, and therefore, a total of 100 patients were included in the study. Patients were eligible for inclusion if they had a history of exposure to an organophosphorous compound and were above 18 years of age. A total of 59 participants (61.5%) required ventilator support, while 37 participants (38.5%) did not, indicating that a significant proportion of the study population experienced respiratory compromise necessitating mechanical ventilation. the association between the presence of intermediate syndrome and the severity of poisoning based on the POP score among the study participants (N=96). None of the participants with mild POP scores developed intermediate syndrome, while 6 participants (13.0%) with moderate scores and 10 participants (55.6%) with severe scores did. This study shows that the POP score, which measures organophosphate poisoning severity, is linked to biochemical markers, clinical outcomes, and sequelae. A substantial fall in serum pseudocholinesterase and a gradual increase in CPK were related to increased poisoning severity, ventilator support, intermediate syndrome, and fatality. All deaths were serious, emphasising the necessity for quick risk assessment. High CPK levels predicted respiratory failure and poor clinical prognosis, while low pseudocholinesterase levels predicted intermediate syndrome and death.
How to cite this article:
Gajula Sudeshna, Vamshi Krishna Gatla, Patchava Alekhya and K. Mohan. Serum Creatine Phosphokinase Levels as Prognostic Biomarker in Organophosphate Poisoning in A Tertiary Care Hospital.
DOI: https://doi.org/10.36478/makrjms.2024.12.944.952
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.944.952