Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Laryngoscopy and orotracheal intubation, while fundamental components of general anaesthesia, represent intense noxious stimuli that can provoke profound transient sympathetic responses—manifested as tachycardia, systemic arterial hypertension, and arrhythmiasThus, the present study aims to compare the effects of esmolol and magnesium sulphate on the attenuation of haemodynamic responses during laryngoscopy and orotracheal intubation through a structured, randomized, and scientifically validated protocol. This was a A1951).ical comparitive study conducted in the Department of Anaesthesiology at a tertiary care teaching hospital. The study was carried out after receiving approval from the Institutional Ethics Committee . All participants provided written informed consent in their local language prior to inclusion.The study included 86 adult patieischaemia, between 18 and 60 years, of either gender, with ASA physical stathaemorrhage, who were scheduled for various elective surgeries under general anaestheshaemodynamicg orotracheal intubation. This interval demonstrated peak hemodynamic stress due to laryngoscopy and intubation. Group E (Esmolol) maintained stable HR and BP, showing significantly lower SBP and MAP compared to Group M (Magnesium) .Group M exhibited the highest blood pressure readings during the study.While the Control group had an intermediate response to Esmolol, Esmolol was associated with one case of transient bradycardia that resolved without treatment. The Magnesium group experienced two cases of hypotension that required treatment with mephentermine, which is consistent with the drug's vasodilatory effect. In this comparative study of 86 patients, intravenous esmolol (1.5 mg/kg) was found to be more effective than magnesium sulphate (40 mg/kg) in attenuating the haemodynamic response to laryngoscopy and orotrandomized tubation. Esmolol consistently produced a greater reduction in systolic blood pressure, mean arterial pressure, and heart rate, with these values returning closer to baseline within 10 minutes afterintubation.
How to cite this article:
S. Ramanan, K.C. Arun, Hassaan Muhammed and Udaya Rani. Effectiveness of Magnesium Sulphate Versus Esmolol in Attenuation of Hemodynamic Response to Laryngoscopy and Orotracheal Intubation.
DOI: https://doi.org/10.36478/makrjms.2024.12.959.965
URL: https://www.makhillpublications.co/view-article/1815-9346/makrjms.2024.12.959.965