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International Journal of Tropical Medicine

ISSN: Online 1818-779X
ISSN: Print 1816-3319
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Severity of Covid‐19 and Co‐Relation with Laboratory Biomarkers: A Cross Sectional Study at Indira Gandhi Medical College and Hospital, Shimla

Gurpreet Singh Kapoor, Rakesh Shandil, Pramod Jaret, Akhilesh Shandil and Anchal Shandil
Page: 141-147 | Received 10 Aug 2023, Published online: 21 Aug 2023

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https://doi.org/10.36478/10.59218/makijtm.2023.141.147

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Abstract

The COVID‐19 pandemic, caused by the SARS‐CoV‐2 virus, has led to significant global health and economic challenges. Understanding the factors that influence disease severity is crucial for effective clinical management and resource allocation. This study aimed to investigate the relationship between disease severity and commonly used laboratory biomarkers among COVID‐19 patients. A hospital‐based cross‐sectional study was conducted at the Isolation Ward of Indira Gandhi Medical College and Hospital, Shimla. A total of 150 COVID‐19 positive patients were enrolled and their demographic, clinical and laboratory data were collected and analyzed. Routine blood parameters, D‐Dimer, CRP, ferritin and HsTrop I levels were investigated. Disease severity was categorized based on established criteria. Statistical analyses were performed to assess associations between biomarker levels and disease severity. The study population comprised mainly individuals aged 51‐60 years (30.7%) and 69.3% were male. Shortness of breath (62.7%), cough (56.0%) and fever (54.7%) were the most common symptoms. Co‐morbidities, including diabetes (28.7%) and hypertension (26.0%), were prevalent. The majority received oxygen through a face mask (56%), while invasive mechanical ventilation was used in 4.7% of cases. Biomarker analysis showed significant associations between elevated D‐Dimer (>2.0 μg mLG1), CRP (>100 mg LG1), ferritin (>1000 ng mLG1), HsTrop I (>15 ng mLG1) and disease severity. In‐hospital mortality was 23.3%. This study highlights the impact of age, gender, co‐morbidities and laboratory biomarkers on COVID‐19 disease severity. The identified biomarkers, including D‐Dimer, CRP, ferritin and HsTrop I, are valuable tools for predicting disease severity and mortality. These findings contribute to the understanding of COVID‐19 patient profiles and outcomes, aiding in clinical decision‐making and resource allocation.

How to cite this article:

Gurpreet Singh Kapoor, Rakesh Shandil, Pramod Jaret, Akhilesh Shandil and Anchal Shandil. Severity of Covid‐19 and Co‐Relation with Laboratory Biomarkers: A Cross Sectional Study at Indira Gandhi Medical College and Hospital, Shimla.
DOI: https://doi.org/10.36478/10.59218/makijtm.2023.141.147
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2023.141.147