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International Journal of Tropical Medicine

ISSN: Online 1818-779X
ISSN: Print 1816-3319
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Retrospective Cohort Study of Correlation Between Inflammatory Markers, its Severity and Prognosis in COVID 19 (SARS) Patients

Nadeem Motlekar, Pranali Shukla, Mrinalini Singh, Javedan Motlekar, Khan Mohammed Soyab and Sabia Siddiqui
Page: 157-162 | Received 31 Jan 2024, Published online: 28 Feb 2024

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https://doi.org/10.36478/10.59218/makijtm.2024.1.157.162

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Abstract

Coronavirus disease‐2019(COVID‐19) caused by SARS Cov‐2. Studies have shown that COVID 19 is a progressive inflammatory process in which clinical deterioration occurs 7‐10 days after onset of disease associated with declining viral titers suggesting pathology is driven by inflammation rather than direct viral injury. Present study was aimed to study correlation between inflammatory markers, its severity and prognosis in COVID 19 (SARS) patients. Present study was Retrospective observational cohort study, conducted in adult hospitalized patients of SARS COV2, nasopharyngeal swab RTPCR positive patients, imaging suggestive of COVID pneumonia. Medical record information including clinical, laboratory as well as outcome data were extracted by using data collection forms. The study consisted of 174 patients, mean age of selected patients was 53.55, most of the patients were in age group of 61‐70 years. About 57.5% patients had mild, 28.7% moderate and 13.4% severe disease based on clinical symptoms and radiological findings. patients 56.9% had mild, 20.1% moderate and 11.5% severe involvement of lungs. patients 10.9% required ICU care during hospital stay. Rest of the patients were under ward care. About 10 patients expired and rest 164 patients recovered from illness. Levels of CRP, ferritin, LDH, ESR, neutrophil to lymphocyte ratio were found to be statistically higher in patients with moderate to severe disease as compared to mild disease. Levels of IL‐6 and PCT were found to be statistically insignificant in this study. Higher levels of IL‐6, LDH, PCT, ESR at the time of admission predicted a worsened outcome. Levels of CRP, ferritin, neutrophil to lymphocyte were found to be statistically insignificant. Immune‐inflammatory parameters such as IL‐6, Ferritin, LDH, WBC, lymphocyte, NLR, PCT and CRP were correlated with disease severity and could be used as potentially important risk factors for disease progression.

How to cite this article:

Nadeem Motlekar, Pranali Shukla, Mrinalini Singh, Javedan Motlekar, Khan Mohammed Soyab and Sabia Siddiqui. Retrospective Cohort Study of Correlation Between Inflammatory Markers, its Severity and Prognosis in COVID 19 (SARS) Patients.
DOI: https://doi.org/10.36478/10.59218/makijtm.2024.1.157.162
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2024.1.157.162