International Journal of Tropical Medicine

117
Views

2
Downloads

Comparative in vitro Activity of Some Macrolide (Erythromycin, Clarithromycin and Azithromycin) and Fluoroquinolone (Ciprofloxacin and Ofloxacin) Antibiotics Against Bacillus anthracis

J. Ngbede , E.B. Ogundeji , D.A. Nyam and R.E.J. Guktur
Page: 36-39 | Received 21 Sep 2022, Published online: 21 Sep 2022

By Research Area

Medicine & Public Health Life Sciences Engineering Mathematics Biomedicine Physics Chemistry Computer Science Earth Sciences Social Sciences Business and Management Psychology Materials Science Economics Education Environment Philosophy Statistics Law Political Science and International Relations Pharmacy Dentistry Energy Linguistics Geography Finance Criminology and Criminal Justice Medicine Cultural and Media Studies History Architecture / Design Literature Biomedical Sciences Religious Studies Education & Language Food Science & Nutrition Public Health

By Volume and Issue

Abstract

In vitro activity of three members of the macrolide group of antibiotics (Erythromycin, Clarithromycin and Azithromycin) and two members of the fluoroquinolone group of antibiotics (Ciprofloxacin and Ofloxacin) were assessed against Bacillus anthracis by standard tube dilution method. All the isolates showed varied susceptibility to the 2 groups of antimicrobial agents. The isolates were susceptible to Ciprofloxacin (MIC₅₀-0.78 µg mL ¹) and Ofloxacin (MIC₅₀-0.31 µg mL ¹) but were resistant to Erythromycin ((MIC₅₀-25 µg mL ¹), Clarithromycin ((MIC₅₀-31.25 µg mL ¹) and Azithromycin ((MIC₅₀-200 µg mL ¹). Comparing the results of the 2 groups of antibiotic susceptibility tests, we do not recommend the use of any of the 3 macrolide antibiotics tested for prophylaxis or therapy of B. anthracis in our geographical area, except with specific result of susceptibility test on the particular isolate(s). Ofloxacin is highly recommended as a good alternative to ciprofloxacin antibiotic.

How to cite this article:

J. Ngbede , E.B. Ogundeji , D.A. Nyam and R.E.J. Guktur . Comparative in vitro Activity of Some Macrolide (Erythromycin, Clarithromycin and Azithromycin) and Fluoroquinolone (Ciprofloxacin and Ofloxacin) Antibiotics Against Bacillus anthracis.
DOI: https://doi.org/10.36478/ijtmed.2008.36.39
URL: https://www.makhillpublications.co/view-article/1816-3319/ijtmed.2008.36.39