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Journal of Dentistry Concerns

ISSN: Online 2706-7459
ISSN: Print 2706-7467
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Expression of IL-1α and PMN Leukocytes in Inflamed Pulp of Wistar Rat After Application of Haruan Fish Extract (Channa striata)

Juni Jekti Nugroho, Andi Sumidarti, Nenny Athriana Farma, Nurhayaty Natsir, Christine Anastasia Rovani, Noor Hikmah, Andi Wisda Martianti and Muh. Harun Achmad
Page: 20-24 | Received 21 Sep 2022, Published online: 21 Sep 2022

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https://doi.org/10.36478/jdc.2020.20.24

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Abstract

Inflammation of permanent teeth that occurs in reversible pulpitis, pulp capping therapy can be done to keep the pulp healthy. Calcium hydroxide is the gold standard material as a capping agent but it has disadvantages due to its high pH. Haruan fish extract (Channa striata) contains active compositions such as albumin, unsaturated fatty acids and important minerals that are needed in the inflammatory process, those can be considered as an alternative medicine to subtitute calcium hydroxide. To determine the effect of the application of haruan fish extracts (Channa striata) on the number of PMN leukocyte cells and the expression of IL-1 Alpha; in the inflamed dental pulp of Wistar rat. Samples were 24 Wistar rats. Experimental animals were divided into 3 groups: negative control group, treatment group (application of haruan fish extract), positive control group (application of calcium hydroxide) to be decapitated in a period of 12 and 72 h. Data were analyzed using the Kruskall Wallis and Chi-square test. There was a decreased in the number of PMN leukocyte cells and low expression of IL-1 Alpha from strong staining to no staining on histological examination and statistical tests (p<0.05) according to observation time 12 and 72 h in the treatment group. Haruan fish extract is effective in decreasing PMN leukocyte infiltration and reducing IL-1α expression.

How to cite this article:

Juni Jekti Nugroho, Andi Sumidarti, Nenny Athriana Farma, Nurhayaty Natsir, Christine Anastasia Rovani, Noor Hikmah, Andi Wisda Martianti and Muh. Harun Achmad. Expression of IL-1α and PMN Leukocytes in Inflamed Pulp of Wistar Rat After Application of Haruan Fish Extract (Channa striata).
DOI: https://doi.org/10.36478/jdc.2020.20.24
URL: https://www.makhillpublications.co/view-article/2706-7467/jdc.2020.20.24